#Genomics
6 posts tagged with "Genomics"
How AlphaGenome Models Gene Regulation: 2D Embeddings, Splicing, and the Race to Read Non-Coding DNA
A technical look at AlphaGenome's architecture, its 2D pairwise embeddings for splicing prediction, and what the model means for clinical variant interpretation.
A Bioinformatician's Guide to Choosing Genomic Foundation Models
A practical guide to selecting genomic foundation models for bioinformatics tasks. Covers ESM-2, DNABERT-2, HyenaDNA, Nucleotide Transformer, scGPT, and Evo with specific recommendations for DNA sequence analysis, protein structure prediction, and single-cell analysis based on hardware requirements, inference speed, and task type.
When the Algorithm Can't Explain Itself: ML Interpretability in Precision Oncology
Machine learning models now outperform FDA-approved biomarkers in predicting treatment response, but the best-performing models often resist explanation. Here's how precision oncology is navigating the trade-off between performance and interpretability.