#Splicing

2 posts tagged with "Splicing"

MIMIC: One 1B Model Across the Central Dogma, and Why Multimodality Beats Scale

2026-05-29T00:00:00Z•36 min read

#foundation-models #computational-biology #multimodal #splicing #protein-design

A 1-billion-parameter model conditioned on RNA chemical-probing reactivity folds a held-out transcript to an F1 of 0.987 against an experimentally guided reference.

How AlphaGenome Models Gene Regulation: 2D Embeddings, Splicing, and the Race to Read Non-Coding DNA

2026-01-29T11:00:00Z•18 min read

#alphagenome #genomics #deep learning #splicing #computational biology #google deepmind #variant interpretation

A technical look at AlphaGenome's architecture, its 2D pairwise embeddings for splicing prediction, and what the model means for clinical variant interpretation.