Structure Without Alignment: How ESM-2 Folds a Single Sequence2026-05-29T00:00:00Z•17 min read#protein-language-models#structure-prediction#esmfold#esm-2#metagenomics#deep-learningESMFold predicts atomic-level structure from a single sequence. No multiple sequence alignment, no database search, no Evoformer churning over homologs.