Paper-reportedRNA & transcriptomesPeer-reviewed2026
ADAR-GPT continual · A-to-I RNA editing site prediction
- Reported score
- 0.763
- Metric
- F1
- Dataset / split
- liver editing sites · 15% validation set
Curriculum plus 15% fine-tuning; 201-nt sequence windows; decision threshold 0.5
Paper-reportedDNA & genomesPeer-reviewed2026
BarcodeBERT (4–4-4) (4–4–4) · unseen-species genus classification
- Reported score
- 78.5%
- Metric
- accuracy
- Dataset / split
- DNA barcodes of unseen species · 1-NN probe
genus-level nearest-neighbor probe on species unseen in training
Paper-reportedDNA & genomesPeer-reviewed2026
Nucleotide Transformer + NN (middle) · gene fusion breakpoint classification
- Reported score
- 0.994
- Metric
- ROC AUC
- Dataset / split
- gene fusion breakpoint DNA sequences · full test set
middle embedding with neural-network classifier
Paper-reportedCells & tissuesPeer-reviewed2026
scLLMDA · Cross-platform scATAC cell-type annotation
- Reported score
- 0.6525
- Metric
- F1
- Dataset / split
- MosA1 reference → WholeBrainA query
Cross-platform reference-query cell-type annotation.
Paper-reportedCells & tissuesPeer-reviewed2026
MINGLE · Cross-platform scATAC cell-type annotation
- Reported score
- 0.6256
- Metric
- F1
- Dataset / split
- MosA1 reference → WholeBrainA query
Cross-platform reference-query comparator.
Paper-reportedRNA & transcriptomesPeer-reviewed2026
ERNIE-RNA + CoBRA · RNA compound-binding site prediction
- Reported score
- 0.657
- Metric
- MCC
- Dataset / split
- CoBRA compound-binding test set · test set
ERNIE-RNA embedding with TCL focal loss
Paper-reportedRNA & transcriptomesPeer-reviewed2026
CUPID Data-aug-Avg · non-coding RNA pairwise interaction prediction
- Reported score
- 0.919
- Metric
- AUROC
- Dataset / split
- ncRNA interaction pairs
Data augmentation with average pooling for molecule-level ncRNA embeddings
Paper-reportedDNA & genomesPeer-reviewed2026
DNABERT-2 · human core-promoter classification
- Reported score
- 70.52%
- Metric
- MCC
- Dataset / split
- GUE H-CPD · paper evaluation
DNABERT-2 comparator in consolidated H-CPD table; rerun provenance not explicit
Paper-reportedRNA & transcriptomesPeer-reviewed2026
ProteinBERT LLM-encoding model · mRNA-protein interaction prediction
- Reported score
- 71.5%
- Metric
- AUROC
- Dataset / split
- mRNA-RBP pairs · RBP-aware test set
LLM encoding of protein partner; RBP-aware partition tests generalization to unseen protein diversity
Paper-reportedCells & tissuesPreprint2026
GREmLN · cell-type annotation
- Reported score
- 0.937
- Metric
- F1
- Dataset / split
- non-immune cells · zero-shot
Zero-shot cell-type annotation using pre-trained cellular graph foundation model
Paper-reportedCells & tissuesPeer-reviewed2026
Best frozen single-cell foundation model · Donor-aware age-class prediction
- Reported score
- 0.322 ± 0.008 standard deviation
- Metric
- Balanced accuracy
- Dataset / split
- AIDA v2 PBMC cohort 622 donors
Same donor-aware splits and logistic-regression probe as expression PCA; text names Geneformer as best model on AIDA v2.
Paper-reportedCells & tissuesPeer-reviewed2026
Gene-expression PCA · Donor-aware age-class prediction
- Reported score
- 0.384
- Metric
- Balanced accuracy
- Dataset / split
- AIDA v2 PBMC cohort 622 donors
Fifty-component gene-expression PCA with the same donor-aware probe splits.
Paper-reportedMolecular interactionsPeer-reviewed2026
TransBind · transcription-factor DNA binding-site prediction
- Reported score
- 0.9508
- Metric
- AUROC
- Dataset / split
- genome-wide TF binding sites · test
Integrates protein and DNA embeddings for TFBS prediction on paper test dataset
Paper-reportedMicrobes & communitiesPreprint2026
EVO2 · Genome-wide prophage detection
- Reported score
- 0.680
- Metric
- MCC
- Dataset / split
- LAMBDA genome-wide prophage test
Genomic language model fine-tuned for prophage detection; genome-wide evaluation.
Paper-reportedMicrobes & communitiesPreprint2026
geNomad · Genome-wide prophage detection
- Reported score
- 0.794
- Metric
- MCC
- Dataset / split
- LAMBDA genome-wide prophage test
Traditional specialist comparator; genome-wide evaluation.
Paper-reportedMolecular interactionsPeer-reviewed2026
MolAS · Physically valid protein–ligand pose selection
- Reported score
- 36.69%
- Metric
- RMSD ≤1 Å and PB-valid success
- Dataset / split
- PoseBusters
Averaged five-fold algorithm-selection performance on PoseBusters; joint RMSD and validity criterion.
Paper-reportedMolecular interactionsPeer-reviewed2026
Single best solver · Physically valid protein–ligand pose selection
- Reported score
- 34.34%
- Metric
- RMSD ≤1 Å and PB-valid success
- Dataset / split
- PoseBusters
Single best solver baseline under the same averaged five-fold selection test.
Paper-reportedProteins & complexesPeer-reviewed2026
GSMFormer-PPI + ProstT5 · protein-protein interaction prediction
- Reported score
- 0.988
- Metric
- AUROC
- Dataset / split
- paper PPI test set · test set
ProstT5 embeddings as graph node features
Paper-reportedMicrobes & communitiesPeer-reviewed2026
NCD-gzip · CAMI II superkingdom read classification
- Reported score
- 0.9804
- Metric
- Macro F1
- Dataset / split
- CAMI II Sample_0 10,000-read subsample 10,000 reads
Superkingdom-level macro-averaged F1; NCD assigns every read.
Paper-reportedMicrobes & communitiesPeer-reviewed2026
NCD-gzip · CAMI II phylum read classification
- Reported score
- 0.1263
- Metric
- Macro F1
- Dataset / split
- CAMI II Sample_0 10,000-read subsample 10,000 reads
Phylum-level macro-averaged F1; distinct taxonomic rank from the other row.
Paper-reportedProteins & complexesPeer-reviewed2026
ESM-2 (8M) · Mutated RBD binding prediction
- Reported score
- 0.0248 ± 0.01
- Metric
- R²
- Dataset / split
- PRIME mutated RBD · position-stratified
Frozen mean-pooled representation with downstream regression; position-stratified split.
Paper-reportedProteins & complexesPeer-reviewed2026
ESM-C (300M) · Mutated RBD binding prediction
- Reported score
- -0.0162 ± 0.01
- Metric
- R²
- Dataset / split
- PRIME mutated RBD · position-stratified
Frozen mean-pooled representation with downstream regression; position-stratified split.
Paper-reportedCells & tissuesPeer-reviewed2026
scGPT + residual geometry · gene-regulatory signal prediction
- Reported score
- 0.677
- Metric
- AUROC
- Dataset / split
- immune tissue
Asymmetric extraction, PCA-64 centered cosine geometry added to scGPT baseline
Paper-reportedRNA & transcriptomesPeer-reviewed2026
RNAret (5-mer) · miRNA-mRNA interaction prediction
- Reported score
- 0.9622
- Metric
- F1
- Dataset / split
- MirTarRAW · held-out test
5-mer RNAret classifier; 72/8/20 train/validation/test split
Paper-reportedProteins & complexesPeer-reviewed2026
SPIN + ESM2-35M (ESM2-35M frozen) · protein function annotation
- Reported score
- 0.796
- Metric
- F1 macro-weighted
- Dataset / split
- TRX · test set
frozen ESM2-35M backbone in SPIN
Paper-reportedCells & tissuesPeer-reviewed2026
scXDR · Cross-dataset single-cell drug response transfer
- Reported score
- 0.8248 ± 0.1573 standard deviation
- Metric
- AUC
- Dataset / split
- scXDR transfer scenario 2
Single-cell-to-single-cell transfer; source scenario 2.
Paper-reportedCells & tissuesPeer-reviewed2026
scVI · Cross-dataset single-cell drug response transfer
- Reported score
- 0.6970 ± 0.2463 standard deviation
- Metric
- AUC
- Dataset / split
- scXDR transfer scenario 2
Single-cell-to-single-cell transfer; source scenario 2.
Paper-reportedDNA & genomesPreprint2026
ARSENAL+ChromBPNet · regulatory-variant scoring
- Reported score
- 0.896 ±0.016
- Metric
- AUROC
- Dataset / split
- Yoruban LCL dsQTLs
Supervised ChromBPNet variant scoring with ARSENAL motif-discovery regularization
Paper-reportedMolecular interactionsPeer-reviewed2026
Chai-1 · Lipid–protein binding pose
- Reported score
- 60.7% 95% CI 55.2–66.0
- Metric
- Success rate, ligand all-atom RMSD <2 Å
- Dataset / split
- LiPP lipid–protein complexes 331 complexes
Top-scoring pose; all-atom lipid RMSD below 2 Å.
Paper-reportedMolecular interactionsPeer-reviewed2026
DiffDock-L · Lipid–protein binding pose
- Reported score
- 46.8% 95% CI 41.3–52.3
- Metric
- Success rate, ligand all-atom RMSD <2 Å
- Dataset / split
- LiPP lipid–protein complexes 331 complexes
Top-scoring pose; all-atom lipid RMSD below 2 Å.
Paper-reportedRNA & transcriptomesPeer-reviewed2025
2OMe-LM · human RNA 2-prime-O-methylation site prediction
- Reported score
- 0.919
- Metric
- AUC
- Dataset / split
- human RNA 2OMe sites · 5-fold cross-validation
pretrained RNA language model predictor
Paper-reportedMolecular interactionsPeer-reviewed2025
Boltz-2 · Ligand potency prediction using generated poses
- Reported score
- 0.800 ± 0.027
- Metric
- Pearson R
- Dataset / split
- SARS-CoV-2 Mpro ligands
Potency prediction using Boltz-2 ligand-pose generation protocol; see paper scoring pipeline.
Paper-reportedMolecular interactionsPeer-reviewed2025
DiffDock · Ligand potency prediction using generated poses
- Reported score
- 0.695 ± 0.037
- Metric
- Pearson R
- Dataset / split
- SARS-CoV-2 Mpro ligands
Potency prediction using DiffDock ligand-pose generation plus paper scoring pipeline; not a native DiffDock affinity score.
Paper-reportedDNA & genomesPreprint2025
PhyloGPN · ClinVar 3-prime UTR variant classification
- Reported score
- 0.94
- Metric
- AUROC
- Dataset / split
- ClinVar 3-prime UTR variants · paper evaluation
log-likelihood-ratio scoring
Paper-reportedMicrobes & communitiesPeer-reviewed2025
NABAS+ · Metagenomic taxonomic classification
- Reported score
- 0.719
- Metric
- F1 score
- Dataset / split
- CAMI II Toy human gastrooral sample19-new
Newly generated sample19 used for classifier comparison.
Paper-reportedMicrobes & communitiesPeer-reviewed2025
MetaPhlAn3 · Metagenomic taxonomic classification
- Reported score
- 0.753
- Metric
- F1 score
- Dataset / split
- CAMI II Toy human gastrooral sample19-new
Newly generated sample19 used for classifier comparison.
Paper-reportedProteins & complexesPeer-reviewed2025
ESM-2 embedding + paper classifier · clathrin protein classification
- Reported score
- 0.916
- Metric
- accuracy
- Dataset / split
- CLA-IND0.6 · independent test
single-feature ESM-2 embedding comparison
Paper-reportedCells & tissuesPeer-reviewed2025
scGen · differentially expressed gene identification
- Reported score
- 0.91
- Metric
- precision at 50% recall
- Dataset / split
- stimulated immune PBMC · CD14+Mono
In-silico perturbation assessment with precision sampled at fixed 50% recall
Paper-reportedCells & tissuesPeer-reviewed2025
Claude 3.5 Sonnet · Single-cell type label annotation
- Reported score
- 84.0% ± 0.7
- Metric
- Binary agreement with manual annotation
- Dataset / split
- AnnDictionary cell-type annotation test
LLM cell-type labels; binary agreement with manual annotations across five replicates.
Paper-reportedCells & tissuesPeer-reviewed2025
GPT-4o · Single-cell type label annotation
- Reported score
- 80.9% ± 0.7
- Metric
- Binary agreement with manual annotation
- Dataset / split
- AnnDictionary cell-type annotation test
LLM cell-type labels; binary agreement with manual annotations across five replicates.
Paper-reportedDNA & genomesPeer-reviewed2025
Caduceus-Ph · Human 5mC detection
- Reported score
- 0.783
- Metric
- AUC
- Dataset / split
- Human 5mC
Binary epigenetic-modification classification as reported in the paper.
Paper-reportedDNA & genomesPeer-reviewed2025
NT-v2 · Human 5mC detection
- Reported score
- 0.7377
- Metric
- AUC
- Dataset / split
- Human 5mC
Binary epigenetic-modification classification as reported in the paper.
Paper-reportedDNA & genomesPeer-reviewed2025
DNABERT-2 (117M) · G-quadruplex classification
- Reported score
- 97.0% ± 0.5
- Metric
- Accuracy
- Dataset / split
- KEx
Pretrained model evaluated on KEx as reported in Table 5.
Paper-reportedDNA & genomesPeer-reviewed2025
Caduceus (8M) · G-quadruplex classification
- Reported score
- 95.0% ± 0.5
- Metric
- Accuracy
- Dataset / split
- KEx
Pretrained model evaluated on KEx as reported in Table 5.
Paper-reportedRNA & transcriptomesPeer-reviewed2025
BiRNA-BERT · extremely long RNA species classification
- Reported score
- 0.804
- Metric
- F1
- Dataset / split
- extremely long-sequence species classification · paper evaluation
adaptive tokenization on full-length long RNA sequences
Paper-reportedMolecular interactionsPreprint2025
Boltz-1 (3 recycling rounds; 200 diffusion steps) · Protein–ligand pose prediction
- Reported score
- 0.545
- Metric
- Top-1 ligand RMSD <2 Å rate
- Dataset / split
- Boltz-1 structure test set
Highest-confidence pose from five samples; precomputed MSAs up to 4,096 sequences.
Paper-reportedProteins & complexesPeer-reviewed2025
CATHe2 + ProstT5 (full ProstT5) · CATH superfamily annotation
- Reported score
- 82.3% ± 1.3 percentage points
- Metric
- F1
- Dataset / split
- CATH superfamily benchmark · paper evaluation
amino-acid and structural alphabet embedding classifier
Paper-reportedCells & tissuesPeer-reviewed2025
Cell-DINO ViT-L · protein localization classification
- Reported score
- 65.5%
- Metric
- F1
- Dataset / split
- HPA-FoV
Self-supervised microscopy embedding pre-trained on HPA-FoV; downstream protein-localization classifier. Dataset-specific pretraining; the paper does not claim a general-purpose foundation model that generalizes beyond these benchmarks.
Paper-reportedMolecular interactionsPeer-reviewed2025
Ibex · Antibody loop structure prediction
- Reported score
- 2.72 Å
- Metric
- Mean CDR H3 RMSD
- Dataset / split
- ImmuneBuilder antibody test set
Backbone RMSD after framework alignment; average over antibody test structures.
Paper-reportedMolecular interactionsPeer-reviewed2025
Chai-1 · Antibody loop structure prediction
- Reported score
- 2.65 Å
- Metric
- Mean CDR H3 RMSD
- Dataset / split
- ImmuneBuilder antibody test set
Backbone RMSD after framework alignment; one seed and one diffusion trajectory.