Protein Design Foundation Models in 2026: Two Ledgers, One Pipeline, Fourteen Models
RFdiffusion2 scaffolded all 41 of 41 enzyme active sites on a benchmark where the prior best deep-learning method managed 16. That gap is the field in one number: diffusion made backbone generation almost routine on paper, and the slow, honest work is finding out how much survives contact with a pipette. Here are the 14 models, sorted by what they can do, what survives the wet lab, and whether you can legally ship them.