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Cells & tissues

Single-cell reference mapping, integration and perturbation. Explore models we could test and the test families that apply to them.

Models to test

These are candidates, not a ranked list. An applicable test may need a trained head, a scoring adapter, a specialist comparison, or access to a hosted service. No result is implied by appearing here.

  • Native prediction
  • Frozen embedding + trained head
  • Specialist / baseline
  • Adapter required
  • Conditional access

Test families

Each candidate test needs a defined dataset, split, metric and run protocol before it can become a benchmark.

Donor-held-out reference mapping

Candidate test

Map unseen donors to a labelled cell-type reference.

Candidate models and comparators

Geneformer
frozen embedding + trained head
scGPT
frozen embedding + trained head
scFoundation
frozen embedding + trained head
scVI
specialist / baseline

Batch integration

Candidate test

Test whether cell identity is retained across donors and batches.

Candidate models and comparators

scGPT
adapter required
scVI
specialist / baseline

Perturbation response

Candidate test

Predict expression changes after unseen perturbations.

Candidate models and comparators

Geneformer
adapter required
scFoundation
adapter required
GEARS
specialist / baseline

Model sources and access descriptions checked 2026-09-16. Confirm licenses, terms and checkpoint revisions before any run.