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Microbes & communities

Microbial sequences and metagenomic classification. Explore models we could test and the test families that apply to them.

Models to test

These are candidates, not a ranked list. An applicable test may need a trained head, a scoring adapter, a specialist comparison, or access to a hosted service. No result is implied by appearing here.

  • Native prediction
  • Frozen embedding + trained head
  • Specialist / baseline
  • Adapter required
  • Conditional access

Kraken2

current database pinned at run timebaseline

Public classifier; database build/version must be pinned separately.

Official source ↗Paper-reported results →

Applicable tests

Held-out-clade classification
specialist / baseline

Remove held-out clades from the reference database; score retained ancestor ranks or unclassified reads, not exact labels absent from the database.

Phage / pathogen reads
specialist / baseline

Native read classification with a pinned reference database.

Test families

Each candidate test needs a defined dataset, split, metric and run protocol before it can become a benchmark.

Bacterial promoter prediction

Candidate test

Classify promoter activity from microbial DNA sequence.

Candidate models and comparators

ProkBERT
frozen embedding + trained head
Evo 2
adapter required

Phage / pathogen reads

Candidate test

Classify held-out phage or pathogen sequences and record taxonomic distance.

Candidate models and comparators

ProkBERT
frozen embedding + trained head
METAGENE-1
frozen embedding + trained head
Kraken2
specialist / baseline

Held-out-clade classification

Candidate test

Hold clades out of downstream fitting and reference databases; evaluate known ancestor labels or unknown-taxon detection, and audit pretraining overlap separately.

Candidate models and comparators

ProkBERT
frozen embedding + trained head
METAGENE-1
frozen embedding + trained head
Evo 2
adapter required
Kraken2
specialist / baseline

Community profiling

Candidate test

Estimate taxon abundances in metagenomic samples.

Candidate models and comparators

MetaPhlAn
specialist / baseline

Model sources and access descriptions checked 2026-09-16. Confirm licenses, terms and checkpoint revisions before any run.